Research Library
Curated research studies organized by category and evidence type. Sample educational content.
GLP-1 Receptor Agonists in Obesity Management: A Comprehensive Review
Wilding JPH, Batterham RL, Calanna S, et al. — The New England Journal of Medicine (2024)
This review summarizes the clinical evidence for GLP-1 receptor agonists in weight management, including semaglutide and tirzepatide, demonstrating significant and sustained weight loss across diverse populations.
DOI on record (10.1056/NEJMra2032183) could not be verified — under owner review.Semaglutide Effects on Kidney Outcomes: FLOW Trial
Perkovic V, Tuttle KR, Rossing P, et al. — New England Journal of Medicine (2024)
The FLOW trial demonstrates that semaglutide 1mg weekly significantly reduces risk of kidney disease progression in patients with type 2 diabetes and chronic kidney disease.
DOI: 10.1056/NEJMoa2403347BPC-157 and Tendon Healing: A Systematic Review of Animal Studies
Krivic A, Anic T, Seiwerth S, et al. — Journal of Orthopedic Research (2023)
This systematic review evaluates the effects of BPC-157 on tendon healing across multiple animal models. Findings consistently demonstrate accelerated tendon-to-bone healing, increased collagen organization, and reduced inflammation markers.
DOI on record (10.1002/jor.35420) could not be verified — under owner review.Semaglutide and Cardiovascular Outcomes: SELECT Trial
Lincoff AM, Brown-Frandsen K, Colhoun HM, et al. — New England Journal of Medicine (2023)
The SELECT trial shows that semaglutide 2.4mg weekly reduces major cardiovascular events by 20% in overweight/obese adults with established cardiovascular disease.
DOI: 10.1056/NEJMoa2307563Retatrutide: Triple Hormone Receptor Agonist for Obesity
Rosenstock J, Frias J, Jastreboff AM, et al. — The Lancet (2023)
Phase 2 trial results for retatrutide show unprecedented weight loss of up to 24.2% at 48 weeks, with improvements in metabolic parameters including HbA1c and triglycerides.
DOI: 10.1016/S0140-6736(23)01053-XBPC-157 Cytoprotective Effects: Multi-Organ Review
Vukojevic J, Siroglavic M, Kasnik K, et al. — Life Sciences (2022)
Comprehensive multi-organ review of BPC-157 cytoprotective effects across GI, CNS, cardiovascular, and musculoskeletal systems in various animal models.
Tirzepatide for Obesity: SURMOUNT-1 Trial Results
Jastreboff AM, Aronne LJ, Ahmad NN, et al. — New England Journal of Medicine (2022)
The SURMOUNT-1 trial demonstrates that tirzepatide produces substantial and sustained weight reduction of up to 22.5% in adults with obesity.
DOI: 10.1056/NEJMoa2206038NAD+ Metabolism and Cellular Aging
Covarrubias AJ, Perrone R, Grozio A, et al. — Nature Reviews Molecular Cell Biology (2021)
This review covers the role of NAD+ in aging, examining how its decline contributes to age-related diseases and how restoration through precursors may support healthy aging.
DOI: 10.1038/s41580-020-00313-xMOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Reynolds JC, Lai RW, Woodhead JST, et al. — Nature Communications (2021)
MOTS-c is identified as an exercise-induced mitochondrial-encoded peptide that regulates physical decline. This study demonstrates its role in muscle homeostasis and metabolic regulation during aging.
DOI: 10.1038/s41467-020-20790-0GHK-Cu Topical Application for Facial Skin Aging
Leyden JJ, Stevens T, Finkey MB, et al. — Journal of Cosmetic Dermatology (2020)
Clinical study demonstrating improvements in skin firmness, clarity, and wrinkle depth with topical GHK-Cu application, with statistical significance versus placebo.
Bremelanotide for Hypoactive Sexual Desire Disorder
Kingsberg SA, Clayton AH, Pfaus JG. — Obstetrics & Gynecology (2019)
Clinical trials of bremelanotide (PT-141) demonstrate significant improvements in desire and distress scores in premenopausal women with HSDD, leading to FDA approval.
DOI on record (10.1097/AOG.0000000000003093) could not be verified — under owner review.BPC-157 Effects on Gastrointestinal Tract: Review
Sikiric P, Rucman R, Turkovic B, et al. — Current Pharmaceutical Design (2018)
Comprehensive review of BPC-157 research in gastrointestinal conditions including inflammatory bowel disease, liver damage, and pancreatic lesions across numerous animal models.
DOI on record (10.2174/1381612824666180418101224) could not be verified — under owner review.NMN Supplementation and NAD+ Restoration in Aging
Yoshino J, Baur JA, Imai S. — Cell Metabolism (2018)
This review examines the evidence for nicotinamide mononucleotide (NMN) supplementation in restoring NAD+ levels and its potential implications for age-related metabolic decline.
DOI: 10.1016/j.cmet.2017.11.002Mitochondrial Peptides and Aging: MOTS-c and Humanin
Kim SJ, Xiao J, Wan J, et al. — Trends in Endocrinology & Metabolism (2017)
Review of mitochondrial-derived peptides including MOTS-c and humanin, examining their roles in metabolic regulation, stress response, and potential anti-aging effects.
DOI on record (10.1016/j.tem.2017.02.005) could not be verified — under owner review.Oxytocin and Social Cognition: A Meta-Analysis
Shamay-Tsoory SG, Abu-Akel A. — Biological Psychiatry (2016)
This meta-analysis evaluates the effects of intranasal oxytocin on social cognition, finding significant improvements in emotion recognition, trust, and social memory.
DOI: 10.1016/j.biopsych.2015.07.020GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
Pickart L, Margolina A. — BioMed Research International (2015)
Gene expression studies reveal that GHK-Cu modulates over 4,000 human genes, with effects on collagen synthesis, anti-oxidant responses, anti-inflammatory pathways, and tissue remodeling processes.
DOI: 10.1155/2015/648108SS-31/Elamipretide: Targeting Mitochondrial Dysfunction
Szeto HH. — Clinical Pharmacology & Therapeutics (2014)
This review discusses the mechanism by which SS-31 targets the inner mitochondrial membrane and its clinical potential for conditions involving mitochondrial dysfunction.
DOI on record (10.1038/clpt.2013.168) could not be verified — under owner review.Tesamorelin and Cognitive Function in Older Adults
Baker LD, Barsness SM, Borber S, et al. — Archives of Neurology (2012)
This study explores the effects of GHRH analog tesamorelin on cognitive function in healthy older adults, showing improvements in executive function and verbal memory.
Semax Neuroprotective Effects in Cerebral Ischemia
Stavchansky VV, Yuzhakov VV, Botsina AYu, et al. — CNS Neuroscience & Therapeutics (2011)
This study demonstrates neuroprotective effects of Semax in experimental cerebral ischemia, with upregulation of neurotrophic factors and reduction in infarct volume.
AOD9604: A Modified GH Fragment for Obesity Treatment
Heffernan M, Summers RJ, Thorburn A, et al. — Journal of Obesity (2011)
This double-blind placebo-controlled study evaluates AOD9604 in obese subjects, demonstrating its fat-reducing effects independent of growth hormone activity.
Selank Anxiolytic Properties and GABA System Modulation
Zozulya AA, Sizov VV, Gabaeva MV, et al. — Bulletin of Experimental Biology and Medicine (2008)
Investigation of Selank peptide reveals anxiolytic activity comparable to benzodiazepines, mediated through GABA receptor modulation without sedative effects.
DOI on record (10.1007/s10517-008-0006-8) could not be verified — under owner review.KPV Tripeptide and Intestinal Inflammation
Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. — Journal of Biological Chemistry (2008)
This study demonstrates that the tripeptide KPV significantly reduces intestinal inflammation by inhibiting NF-kB activation and suppressing pro-inflammatory cytokine production.
DOI on record (10.1074/jbc.M801738200) could not be verified — under owner review.Tesamorelin for Visceral Fat Reduction in HIV Lipodystrophy
Falutz J, Allas S, Blot K, et al. — New England Journal of Medicine (2007)
This pivotal trial demonstrates that tesamorelin significantly reduces visceral adipose tissue in HIV-infected patients with lipodystrophy, leading to FDA approval.
DOI on record (10.1056/NEJMoa074158) could not be verified — under owner review.CJC-1295 and Prolonged GH Secretion in Healthy Adults
Teichman SL, Neale A, Lawrence B, et al. — Journal of Clinical Endocrinology & Metabolism (2006)
This clinical trial demonstrates that CJC-1295 produces dose-dependent increases in GH and IGF-1 levels with sustained duration, suggesting utility for GH deficiency investigation.
DOI on record (10.1210/jc.2005-1601) could not be verified — under owner review.IGF-1 LR3 and Skeletal Muscle Hypertrophy
Barton ER. — Growth Hormone & IGF Research (2006)
Review of IGF-1 and its analogs including LR3 in promoting skeletal muscle hypertrophy through satellite cell activation and protein synthesis pathways.
Thymosin Beta-4 in Cardiac Repair After Myocardial Infarction
Bock-Marquette I, Saxena A, White MD, et al. — Nature (2004)
This study demonstrates that Thymosin Beta-4 activates integrin-linked kinase and promotes cardiac cell migration, survival, and repair after myocardial infarction in animal models.
DOI on record (10.1038/nature02582) could not be verified — under owner review.Epitalon and Telomerase Activation in Human Somatic Cells
Khavinson VK, Bondarev IE, Butyugov AA. — Bulletin of Experimental Biology and Medicine (2003)
This study demonstrates that the tetrapeptide Epitalon activates telomerase in human somatic cells and promotes telomere elongation, with implications for aging research.
Ipamorelin: The First Selective Growth Hormone Secretagogue
Raun K, Hansen BS, Johansen NL, et al. — European Journal of Endocrinology (1998)
This study characterizes Ipamorelin as a highly selective growth hormone secretagogue that stimulates GH release without affecting cortisol, prolactin, or other hormones.
DOI: 10.1530/eje.0.1390552Melanotan II and Melanogenesis: Clinical Observations
Dorr RT, Lines R, Levine N, et al. — Life Sciences (1996)
This clinical study evaluates the tanning and side effect profile of Melanotan II in human subjects, demonstrating significant melanogenesis with notable side effects including nausea.
DSIP and Sleep Architecture Modulation in Humans
Schneider-Helmert D, Schoenenberger GA. — Psychopharmacology (1983)
This study evaluates the effects of DSIP on human sleep patterns, demonstrating modulation of sleep architecture and improved sleep quality in insomnia patients.
Research entries are sample educational content for demonstration purposes. Verify all citations through original sources.